ea0065op1.4 | Adrenal and Cardiovascular | SFEBES2019
Leslie Fiona
, Kershaw Stephen
, Pfander Pauline
, Poolman Toryn
, McGinnis Kathryn
, Frankavilla Chiara
, Ray David
, Cook Graham
, Matthews Laura
Glucocorticoids (Gc) are potent anti-inflammatory steroids which mediate their effects by binding the glucocorticoid receptor (GR). Following ligand binding, GR initiates rapid non-genomic kinase signals in the cytoplasm, then translocates into the nucleus to mediate genomic effects by binding DNA directly or tethering to other DNA bound transcription factors to modulate target gene expression. Little is known about how rapidly induced cytoplasm derived...